Posts in August 2017

  1. Editing Embryos

    [ By on August 03, 2017 ]

    There are several biotech dreams that I didn't think would be realized in my lifetime - cloning an organism and relatively simple gene editing of a human embryo.  I'm 0 for 2.  Read for yourself here and here.  (I was surprised to see that the disorder they were working with was Hypertrophic Cardiomyopathy; my lab from graduate school worked on genes / proteins associated with this disease). Wow. A few thoughts in the scientific and ethical domains. 1 - The efficiency rate is quite high - 72%.  The problem with earlier gene editing techniques was the abysmally low efficiency rate. 2 - This paper reported on correction of mistakes from the male (from the sperm) with a wild type female (egg).  Obviously, ...

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  2. How sure are we that football leads to CTE?

    [ By on August 03, 2017 ]

    When I meet people and let them know I'm from Pittsburgh, it becomes immediately evident that I am a football fan.  Given that, how are we to interpret the information about the relationship between football and Chronic Traumatic Encephalopathy? First, it must be emphasized that this is a "convenience sample" meaning that it is not necessarily representative of all football players.  Indeed, these players donated their brains for research; one could ask why they did so.  Second, the evaluations were completed "blind" which means that those observing the brains did not know whose brain it was or whether they had played football for a long time in a high hit position.  In addition, the evaluations were replicated four times.  Third, ...

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