Posts in February 2016

  1. Optimizing Conditions for the Yield of One Side Bound IgG Protein Compounds

    [ February 09, 2016 ]

    An antibody, also known as an immunoglobulin, is a large protein that can bind to foreign bodies, e.g. microbes or infected cells, and trigger an attack by other components of the immune system, or can neutralize its target directly. Antibodies are “Y” shaped, with two heavy chains composing the base of the “Y” and a light chain and variable region composing the two upper arms of the “Y”. Research has shown that when attaching molecules to antibodies for use in targeted drug therapies, it is preferable to control the site of attachment so as not to interfere with the antibody’s ability to bind its target antigen. Due to the symmetric nature of antibodies, even when using site-specific conjugation methods, the ...

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