Posts in Life Sciences

  1. Optimizing Conditions for the Yield of One Side Bound IgG Protein Compounds

    [ February 09, 2016 ]

    An antibody, also known as an immunoglobulin, is a large protein that can bind to foreign bodies, e.g. microbes or infected cells, and trigger an attack by other components of the immune system, or can neutralize its target directly. Antibodies are “Y” shaped, with two heavy chains composing the base of the “Y” and a light chain and variable region composing the two upper arms of the “Y”. Research has shown that when attaching molecules to antibodies for use in targeted drug therapies, it is preferable to control the site of attachment so as not to interfere with the antibody’s ability to bind its target antigen. Due to the symmetric nature of antibodies, even when using site-specific conjugation methods, the ...

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  2. Expression of Hsp70 in Spartina alterniflora as a bio-indicator for environmental impact

    [ November 18, 2014 ]

    The long-term goal of our research is to evaluate the health of the Bronx River, Bronx, NY by gauging the effect of environmental stresses on organisms native to the river. Due to the heavy dumping of industrial waste and nearby urbanization, the Bronx River has experienced a dramatic decline in water quality and estuarine health. Specifically, we explored the role of smooth cord grass, Spartina alterniflora, as an indicator of relative environmental stress. Our approach was to monitor expression of the universal stress responding protein, heat shock protein 70 (Hsp70) in grass collected from the Bronx River estuary as well as a relatively less impacted site in Greenwich Cove, Greenwich, CT. We quantified and compared constitutive and heat-induced expression of ...

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  3. Tigers

    [ May 23, 2014 ]

    The tiger, or Panthera tigris, is one of the hallmark “big cats”. It is seemingly an all-powerful force in its wild-habitat, fearless and dominant over most other species. However, we often forget that the human species has an enormous influence over its survival. Humans have played an integral role in the gradual extinction of the tiger. Tigers are disappearing at an alarming rate and in the last century alone, three subspecies of the tiger have gone extinct. Less than 3200 tigers are currently living in the wild, securing these cats a spot on the endangered species list. The monetary value of the tiger’s famous striped coat has made it a highly desired animal in the illicit wildlife trade. Additionally, medicinal repurposing ...

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